A team of NYU researchers has tackled the longstanding question of how to build ultra-sensitive, ultra-small electrochemical sensors with homogeneous and predictable properties, by discovering how to engineer graphene structure on an atomic level. The team's findings could benefit biochemical detection, environmental monitoring, and lab-on-a-chip applications

Finely tuned electrochemical sensors (also referred to as electrodes) that are as small as biological cells have tremendous potential for medical diagnostics and environmental monitoring systems. However, efforts to develop them have encountered obstacles, like the lack of quantitative principles to guide the precise engineering of the electrode sensitivity to biochemical molecules.

Davood Shahrjerdi, an assistant professor of electrical and computer engineering at NYU Tandon School, and Roozbeh Kiani, an assistant professor of neural science and psychology at the Center for Neural Science, have revealed the relationship between various structural defects in graphene and the sensitivity of the electrodes made of it. This discovery opens the door for the precise engineering and industrial-scale production of homogeneous arrays of graphene electrodes.

Ther team explains that there is a traditional consensus that structural defects in graphene can generally enhance the sensitivity of electrodes constructed from it. However, a firm understanding of the relationship between various structural defects and the sensitivity has long eluded researchers. This information is particularly vital for tuning the density of different defects in graphene in order to achieve a desired level of sensitivity.

“Until now, achieving a desired sensitivity effect was akin to voodoo or alchemy — oftentimes, we weren’t sure why a certain approach yielded a more or less sensitive electrode,” Shahrjerdi said. “By systematically studying the influence of various types and densities of material defects on the electrode’s sensitivity, we created a physics-based microscopic model that replaces superstition with scientific insight.”

The researchers discovered that only one group of defects in graphene’s structure — point defects — significantly impacts electrode sensitivity, which increases linearly with the average density of these defects, within a certain range. “If we optimize these point defects in number and density, we can create an electrode that is up to 20 times more sensitive than conventional electrodes,” Kiani explained.